IM/IV Vag delivery 100 mcg/mL as single dose IM or by slow IV inj over 1 min. Administer only after delivery of the infant & as soon as possible after delivery, preferably before delivery of placenta. IVCaesarean section under epidural or spinal anaesth 100 mcg/mL as single dose by slow IV inj over 1 min. Administer only after delivery of the infant & as soon as possible after delivery, preferably before delivery of placenta.
Not appropriate to use at any stage before delivery of the infant. Consider additional therapy w/ another uterotonic in case of persisting uterine hypotonia or atonia & consequent excessive bleeding. Epilepsy, migraine, asthma, CV disease or any state in which rapid addition to extracellular water may produce hazard for an already overburdened system. Carefully monitor patients w/ eclampsia & pre-eclampsia. Possible hyponatraemia particularly in patients receiving large vol of IV fluids. Recognize early signs of drowsiness, listlessness & headache to prevent convulsions & coma. Gestational DM. Adolescent & childn <12 yr.
Risk of severe HTN when given 3-4 hr following prophylactic administration of a vasoconstrictor in conjunction w/ caudal-block anaesth. May enhance BP-enhancing effects of ergot-alkaloids (eg, methylergometrine). Hypotensive effect may be enhanced & effect on the uterus may be weakened by some inhalation anaesth (eg, halothane, cyclopropane). Possible arrhythmias for oxytocin during concomitant use.
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